His marriage to Lady Margaret Clifford, was held in presence of Queen Mary and Felipe of Spain in the Royal Chapel at the Palace of Whitehall. Henry was created Knight of the Garter by Queen Elizabeth in 1574. Appointed Ambassador to the court of Henry III of France in 1580. Appointed to the Privy Council in 1585. Was among the chief officials of the trial of the deposed Mary, Queen of Scots in 1586.
In 1588, he was part of a mission which tried to negotiate an end to the Anglo-Spanish War, following the defeat of the Spanish Armada. While in 1589, Queen Elizabeth appointed him Lord High Steward for the trial of Philip Howard, Earl of Arundel and Surrey.
He returned to Lathom in retirement in 1592 and died there in 1593.
Titles: 4th Earl of Derby and 8th Lord (Baron) Mohun. Knight of the Order of the Bath in 1547. 12th Lord (Baron) Strange of Knokyn. Lord Lieutenant of Cheshire between 1572 and 1593. Chamberlain of Chester between 1588 and 1593.